## Copy number aberrations / Detect genes from called copy number data

### Description

Using the chromosomal locations of the data points in copy number data set, convert the data from probe/bin-based to gene-based. The probes/bins from which the copy number call for a given gene are determined as follows. If there are probes/bins overlapping with the position of the gene, they are used. In case of no overlaps, the last preceding and first tailing probe/bin are used.

### Parameters

- Method to use to determine calls for the genes (majority, unambiguous) [majority]
- Method to use for other data columns (mean, median) [mean]
- Human genome build to use (GRCh37/hg19, NCBI36/hg18, NCBI35/hg17, NCBI34/hg16) [GRCh37/hg19]

### Details

The list of Ensembl genes is retrieved, and the input data converted from probe/bin-based to gene-based. For a given gene, the probes/bins to use are determined as described in the referenced CanGEM paper. The majority method means that the gene is marked as a loss (or gain), if more than 50% of the determined probes/bins show a loss (or a gain). The unambiguous method requires that all of the probes/bins have to give the same signal, or otherwise the gene is marked as normal copy number.

### Output

Input data set transferred from probe/bin-based to gene-based measurements.

### References

CanGEM:
Scheinin et al. (2008) CanGEM: mining gene copy number changes in cancer. Nucleic Acids Res 36: D830-D835

Ensembl:
Flicek et al. (2010) Ensembl's 10th year. Nucleic Acids Res 38: D557-62